Oprah Winfrey's GLP-1 Side Effect: How She Overcame Constipation with Water & Magnesium (2026)

Oprah's Weight Loss Journey: A Surprising Side Effect Unveiled

In a recent interview, Oprah Winfrey shared her experience with a GLP-1 weight-loss drug and the unexpected side effect it brought to light. But here's where it gets intriguing: it's not the typical nausea or diarrhea that most people associate with these medications.

The Uncommon Side Effect: Constipation and Its Solution

Oprah revealed that while she didn't suffer from nausea or diarrhea, she did encounter constipation. "I finally discovered the perfect blend of magnesium and water for my body," she explained. "I need to drink a gallon of water daily, and it has to be done before 4 p.m. or I'm up all night."

Water, as we know, is essential for softening stools and aiding digestion. Magnesium citrate, as supported by the National Library of Medicine, helps retain water in the stool, making it softer and easier to pass, and increasing bowel movement frequency.

Oprah's Success Story and Her Doctor's Take

In her new book, "Enough: Your Health, Your Weight, and What It’s Like to Be Free," Oprah writes about her successful weight loss journey with GLP-1 drugs. Dr. Ania Jastreboff, an endocrinologist and associate professor at the Yale School of Medicine, co-authored the book with Oprah and shared her insights.

"Oprah's kidneys are thriving," Dr. Jastreboff said, emphasizing the importance of considering the risk-to-benefit ratio for any medication. She also highlighted hydration as a key strategy to mitigate nausea, a common side effect of GLP-1 drugs, along with gradually increasing the medication dose.

"Start low and go slow. If you're feeling nauseated, hold off on increasing the dose," she advised. "There are other strategies too, like not overeating and monitoring foods that might aggravate symptoms. These can all help reduce side effects."

A Word from the Health Reporter

A. Pawlowski, a health reporter for TODAY, has focused on health news and features. Previously, she worked as a writer, producer, and editor at CNN. Pawlowski's expertise adds depth to the discussion on weight loss, medication, and side effects.

The Takeaway: Weighing Benefits and Risks

Every medication comes with potential side effects, and it's crucial to understand the balance between benefits and risks. While GLP-1 drugs can aid weight loss, they may also bring about gastrointestinal issues. However, with proper management and strategies like hydration and gradual dose increases, these side effects can be minimized.

What's your take on this? Do you think the benefits of GLP-1 drugs outweigh the potential side effects? Share your thoughts in the comments below!

Oprah Winfrey's GLP-1 Side Effect: How She Overcame Constipation with Water & Magnesium (2026)
Top Articles
Latest Posts
Recommended Articles
Article information

Author: Rev. Leonie Wyman

Last Updated:

Views: 6485

Rating: 4.9 / 5 (79 voted)

Reviews: 94% of readers found this page helpful

Author information

Name: Rev. Leonie Wyman

Birthday: 1993-07-01

Address: Suite 763 6272 Lang Bypass, New Xochitlport, VT 72704-3308

Phone: +22014484519944

Job: Banking Officer

Hobby: Sailing, Gaming, Basketball, Calligraphy, Mycology, Astronomy, Juggling

Introduction: My name is Rev. Leonie Wyman, I am a colorful, tasty, splendid, fair, witty, gorgeous, splendid person who loves writing and wants to share my knowledge and understanding with you.